Hi,
I am outlining an online science game which would be using framstick as
the evolutionary framework. I can expand on this if anyone is interested
but the gist is that player will manage a research group to find
"centiframes" and attempt to figure out where they come from and how
they evolved. For this to work, I need to have as many feature to work
on the command line so it can be handled by the web server.
Is there a way that I can compute dissimilarity measures between two
genomes from the command line?
Christian

Yes, this is possible and
Yes, this is possible and quite often used. Look for "cliutils.ini" file in the distribution and you will find a handful of useful commands there, including the ability to compute dissimilarity for a set of genotypes.